CCI-779 inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to targeting mTOR/Hif- 1α/VEGF signaling
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چکیده
INTRODUCTION. Angiogenesis is one of the critical steps in tumor growth and metastasis. Much attention over the years has been devoted to the notion that tumor blood supply can be targeted with antiangiogenic agents. Our recent study has demonstrated that a mechanism of ezrin-related metastatic behavior is linked to an mTOR pathway, and blockade of this pathway by rapamycin and its analogue CCI-779 led to inhibition of ezrin-mediated metastatic behavior in a murine model of osteosarcoma (1,2). The goal of this study was to evaluate whether the antitumor activity of CCI-779 is related to antiangiogenic effects in vivo in tumors of mice bearing human rhabdomyosarcoma xenografts.
منابع مشابه
CCI-779 inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/Hif-1alpha/VEGF signaling.
Angiogenesis is one of the critical steps in tumor growth and metastasis. The goal of this study was to evaluate whether the antitumor activity of CCI-779 is related to antiangiogenic effects in vivo in tumors of mice bearing human rhabdomyosarcoma (RMS) xenografts. We now demonstrate that CCI-779 rapidly inhibits mTOR activity, as indicated by S6 reduction and eukaryotic initiation factor 4E-b...
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